Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced express...
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
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Author / Creator
Jarvis, Lorna B. , Rainbow, Daniel B. , Coppard, Valerie , Howlett, Sarah K. , Georgieva, Zoya , Davies, Jessica L. , Mullay, Harpreet Kaur , Hester, Joanna , Ashmore, Tom , Van Den Bosch, Aletta , Grist, James T. , Coles, Alasdair J. , Mousa, Hani S. , Pluchino, Stefano , Mahbubani, Krishnaa T. , Griffin, Julian L. , Saeb-Parsy, Kourosh , Issa, Fadi , Peruzzotti-Jametti, Luca , Wicker, Linda S. and Jones, Joanne L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing their function, phenotype and transcriptomic profile against ex vivo Tregs, we demonstrate that expa...
Alternative Titles
Full title
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
Authors, Artists and Contributors
Author / Creator
Rainbow, Daniel B.
Coppard, Valerie
Howlett, Sarah K.
Georgieva, Zoya
Davies, Jessica L.
Mullay, Harpreet Kaur
Hester, Joanna
Ashmore, Tom
Van Den Bosch, Aletta
Grist, James T.
Coles, Alasdair J.
Mousa, Hani S.
Pluchino, Stefano
Mahbubani, Krishnaa T.
Griffin, Julian L.
Saeb-Parsy, Kourosh
Issa, Fadi
Peruzzotti-Jametti, Luca
Wicker, Linda S.
Jones, Joanne L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_45140660645e4b33867eb3d5efef93f6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_45140660645e4b33867eb3d5efef93f6
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-021-02721-x
