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Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks

Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_45329759f9064b0e8296aa47bf2e87c6

Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks

About this item

Full title

Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks

Publisher

London: Nature Publishing Group UK

Journal title

Molecular systems biology, 2025-01, Vol.21 (3), p.274-293

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Metabolic variation across pathogenic bacterial strains can impact their susceptibility to antibiotics and promote the evolution of antimicrobial resistance (AMR). However, little is known about how metabolic mutations influence metabolism and which pathways contribute to antibiotic susceptibility. Here, we measured the antibiotic susceptibility of...

Alternative Titles

Full title

Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_45329759f9064b0e8296aa47bf2e87c6

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_45329759f9064b0e8296aa47bf2e87c6

Other Identifiers

ISSN

1744-4292

E-ISSN

1744-4292

DOI

10.1038/s44320-024-00084-z

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