MRGPRX4 is a bile acid receptor for human cholestatic itch
MRGPRX4 is a bile acid receptor for human cholestatic itch
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Author / Creator
Yu, Huasheng , Zhao, Tianjun , Liu, Simin , Wu, Qinxue , Johnson, Omar , Wu, Zhaofa , Zhuang, Zihao , Shi, Yaocheng , Peng, Luxin , He, Renxi , Yang, Yong , Sun, Jianjun , Wang, Xiaoqun , Xu, Haifeng , Zeng, Zheng , Zou, Peng , Lei, Xiaoguang , Luo, Wenqin and Li, Yulong
Publisher
England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
Patients with liver diseases often suffer from chronic itch, yet the pruritogen(s) and receptor(s) remain largely elusive. Here, we identify bile acids as natural ligands for MRGPRX4. MRGPRX4 is expressed in human dorsal root ganglion (hDRG) neurons and co-expresses with itch receptor HRH1. Bile acids elicited Ca2+ responses in cultured hDRG neuron...
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Full title
MRGPRX4 is a bile acid receptor for human cholestatic itch
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TN_cdi_doaj_primary_oai_doaj_org_article_4548ec382217470083b1f9c69579733d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4548ec382217470083b1f9c69579733d
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.48431
