α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
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London: BioMed Central
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Language
English
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London: BioMed Central
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Contents
Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol
SNCA
), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleinopathies. Several findings in experimental models implicate perturbations in the tissue homeostatic mechanisms triggered by pathological aSyn accumulat...
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Full title
α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
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TN_cdi_doaj_primary_oai_doaj_org_article_4556178dc7c94ccab3861fb11cbb6d65
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4556178dc7c94ccab3861fb11cbb6d65
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-021-01209-3
