Immune Factor, TNFα, Disrupts Human Brain Organoid Development Similar to Schizophrenia—Schizophreni...
Immune Factor, TNFα, Disrupts Human Brain Organoid Development Similar to Schizophrenia—Schizophrenia Increases Developmental Vulnerability to TNFα
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Lausanne: Frontiers Research Foundation
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Language
English
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Lausanne: Frontiers Research Foundation
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Schizophrenia (SZ) is a neurodevelopmental genetic disorder in which maternal immune activation (MIA) and increased Tumor Necrosis Factor-α (TNF) may contribute. Previous studies using iPSC-derived cerebral organoids and neuronal cells demonstrated developmental malformation and transcriptional dysregulations, including TNF receptors and their sign...
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Immune Factor, TNFα, Disrupts Human Brain Organoid Development Similar to Schizophrenia—Schizophrenia Increases Developmental Vulnerability to TNFα
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TN_cdi_doaj_primary_oai_doaj_org_article_45bfad2173fe44148cbaebd3973665a1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_45bfad2173fe44148cbaebd3973665a1
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ISSN
1662-5102
E-ISSN
1662-5102
DOI
10.3389/fncel.2020.00233
