Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architectu...
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
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Author / Creator
Jiang, Xia , O’Reilly, Paul F. , Aschard, Hugues , Hsu, Yi-Hsiang , Richards, J. Brent , Dupuis, Josée , Ingelsson, Erik , Karasik, David , Pilz, Stefan , Berry, Diane , Kestenbaum, Bryan , Zheng, Jusheng , Luan, Jianan , Sofianopoulou, Eleni , Streeten, Elizabeth A. , Lutsey, Pamela L. , Yao, Lu , Tang, Weihong , Wallaschofski, Henri , Völzke, Henry , Zhou, Ang , Power, Chris , McCarthy, Mark I. , Michos, Erin D. , Boerwinkle, Eric , Weinstein, Stephanie J. , Freedman, Neal D. , Huang, Wen-Yi , Van Schoor, Natasja M. , van der Velde, Nathalie , Groot, Lisette C. P. G. M. de , Enneman, Anke , Cupples, L. Adrienne , Booth, Sarah L. , Vasan, Ramachandran S. , Liu, Ching-Ti , Zhou, Yanhua , Ripatti, Samuli , Ohlsson, Claes , Vandenput, Liesbeth , Lorentzon, Mattias , Eriksson, Johan G. , Shea, M. Kyla , Houston, Denise K. , Kritchevsky, Stephen B. , Liu, Yongmei , Lohman, Kurt K. , Ferrucci, Luigi , Peacock, Munro , Gieger, Christian , Beekman, Marian , Slagboom, Eline , Deelen, Joris , Heemst, Diana van , Kleber, Marcus E. , März, Winfried , de Boer, Ian H. , Wood, Alexis C. , Rotter, Jerome I. , Rich, Stephen S. , Robinson-Cohen, Cassianne , den Heijer, Martin , Jarvelin, Marjo-Riitta , Cavadino, Alana , Joshi, Peter K. , Wilson, James F. , Hayward, Caroline , Lind, Lars , Michaëlsson, Karl , Trompet, Stella , Zillikens, M. Carola , Uitterlinden, Andre G. , Rivadeneira, Fernando , Broer, Linda , Zgaga, Lina , Theodoratou, Evropi , Farrington, Susan M. , Timofeeva, Maria , Dunlop, Malcolm G. , Valdes, Ana M. , Tikkanen, Emmi , Lehtimäki, Terho , Lyytikäinen, Leo-Pekka , Kähönen, Mika , Raitakari, Olli T. , Mikkilä, Vera , Ikram, M. Arfan , Sattar, Naveed , Jukema, J. Wouter , Wareham, Nicholas J. , Langenberg, Claudia , Gundersen, Thomas E. , Khaw, Kay-Tee , Butterworth, Adam S. , Danesh, John , Spector, Timothy , Wang, Thomas J. , Hyppönen, Elina , Kraft, Peter and Kiel, Douglas P.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (
GC, NADSYN1/DHCR7, CYP2R1, CYP24A1
). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,...
Alternative Titles
Full title
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
Authors, Artists and Contributors
Author / Creator
O’Reilly, Paul F.
Aschard, Hugues
Hsu, Yi-Hsiang
Richards, J. Brent
Dupuis, Josée
Ingelsson, Erik
Karasik, David
Pilz, Stefan
Berry, Diane
Kestenbaum, Bryan
Zheng, Jusheng
Luan, Jianan
Sofianopoulou, Eleni
Streeten, Elizabeth A.
Lutsey, Pamela L.
Yao, Lu
Tang, Weihong
Wallaschofski, Henri
Völzke, Henry
Zhou, Ang
Power, Chris
McCarthy, Mark I.
Michos, Erin D.
Boerwinkle, Eric
Weinstein, Stephanie J.
Freedman, Neal D.
Huang, Wen-Yi
Van Schoor, Natasja M.
van der Velde, Nathalie
Groot, Lisette C. P. G. M. de
Enneman, Anke
Cupples, L. Adrienne
Booth, Sarah L.
Vasan, Ramachandran S.
Liu, Ching-Ti
Zhou, Yanhua
Ripatti, Samuli
Ohlsson, Claes
Vandenput, Liesbeth
Lorentzon, Mattias
Eriksson, Johan G.
Shea, M. Kyla
Houston, Denise K.
Kritchevsky, Stephen B.
Liu, Yongmei
Lohman, Kurt K.
Ferrucci, Luigi
Peacock, Munro
Gieger, Christian
Beekman, Marian
Slagboom, Eline
Deelen, Joris
Heemst, Diana van
Kleber, Marcus E.
März, Winfried
de Boer, Ian H.
Wood, Alexis C.
Rotter, Jerome I.
Rich, Stephen S.
Robinson-Cohen, Cassianne
den Heijer, Martin
Jarvelin, Marjo-Riitta
Cavadino, Alana
Joshi, Peter K.
Wilson, James F.
Hayward, Caroline
Lind, Lars
Michaëlsson, Karl
Trompet, Stella
Zillikens, M. Carola
Uitterlinden, Andre G.
Rivadeneira, Fernando
Broer, Linda
Zgaga, Lina
Theodoratou, Evropi
Farrington, Susan M.
Timofeeva, Maria
Dunlop, Malcolm G.
Valdes, Ana M.
Tikkanen, Emmi
Lehtimäki, Terho
Lyytikäinen, Leo-Pekka
Kähönen, Mika
Raitakari, Olli T.
Mikkilä, Vera
Ikram, M. Arfan
Sattar, Naveed
Jukema, J. Wouter
Wareham, Nicholas J.
Langenberg, Claudia
Gundersen, Thomas E.
Khaw, Kay-Tee
Butterworth, Adam S.
Danesh, John
Spector, Timothy
Wang, Thomas J.
Hyppönen, Elina
Kraft, Peter
Kiel, Douglas P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_45ceebb3cb0e4473b2cfdeb800d4099c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_45ceebb3cb0e4473b2cfdeb800d4099c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02662-2
