The Bioactivity of D-/L-Isonucleoside- and 2′-Deoxyinosine-Incorporated Aptamer AS1411s Including DN...
The Bioactivity of D-/L-Isonucleoside- and 2′-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression
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Author / Creator
Fan, Xinmeng , Sun, Lidan , Li, Kunfeng , Yang, Xiantao , Cai, Baobin , Zhang, Yanfen , Zhu, Yuejie , Ma, Yuan , Guan, Zhu , Wu, Yun , Zhang, Lihe and Yang, Zhenjun
Publisher
United States: Elsevier Inc
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Language
English
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Publisher
United States: Elsevier Inc
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Contents
In this study, chemical modification of 2′-deoxyinosine (2′-dI) and D-/L-isothymidine (D-/L-isoT) was performed on AS1411. They could promote the nucleotide-protein interaction by changing the local conformation. Twenty modified sequences were obtained, FCL-I and FCL-II showed the most noticeable activity improvement. They stabilized the G-quadrupl...
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Full title
The Bioactivity of D-/L-Isonucleoside- and 2′-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression
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TN_cdi_doaj_primary_oai_doaj_org_article_45d9c6b5f7e94c8580dd01ea39d23cbd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_45d9c6b5f7e94c8580dd01ea39d23cbd
Other Identifiers
ISSN
2162-2531
E-ISSN
2162-2531
DOI
10.1016/j.omtn.2017.09.010
