Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM
Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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DNA polymerase theta (Polθ) is a DNA helicase-polymerase protein that facilitates DNA repair and is synthetic lethal with homology-directed repair (HDR) factors. Thus, Polθ is a promising precision oncology drug-target in HDR-deficient cancers. Here, we characterize the binding and mechanism of action of a Polθ helicase (Polθ-hel) small-molecule in...
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Full title
Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM
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TN_cdi_doaj_primary_oai_doaj_org_article_46164b5688fb4f7488433df9b86a86b9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_46164b5688fb4f7488433df9b86a86b9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-51351-4
