Pharmacological Targeting of CSF1R Inhibits Microglial Proliferation and Aggravates the Progression...
Pharmacological Targeting of CSF1R Inhibits Microglial Proliferation and Aggravates the Progression of Cerebral Ischemic Pathology
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Author / Creator
Hou, Boru , Jiang, Cheng , Wang, Dong , Wang, Gang , Wang, Zening , Zhu, Miaojuan , Kang, Yuchen , Su, Jiacheng , Wei, Pengfei , Ren, Haijun and Ju, Furong
Publisher
Lausanne: Frontiers Research Foundation
Journal title
Language
English
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Publication information
Publisher
Lausanne: Frontiers Research Foundation
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Scope and Contents
Contents
Ischaemic stroke can induce rapid activation of microglia. It has been reported that the microglia’s survival is dependent on colony-stimulating factor 1 receptor (CSF1R) signalling and that pharmacological inhibition of CSF1R leads to morphological changes in microglia in the healthy brain. However, the impact of CSF1R inhibition on neuronal struc...
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Full title
Pharmacological Targeting of CSF1R Inhibits Microglial Proliferation and Aggravates the Progression of Cerebral Ischemic Pathology
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_461ea60fd009493fbf73ad62c4633c2f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_461ea60fd009493fbf73ad62c4633c2f
Other Identifiers
ISSN
1662-5102
E-ISSN
1662-5102
DOI
10.3389/fncel.2020.00267
