Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans
Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans
About this item
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Author / Creator
Kaasinen, Eevi , Kuismin, Outi , Rajamäki, Kristiina , Ristolainen, Heikki , Aavikko, Mervi , Kondelin, Johanna , Saarinen, Silva , Berta, Davide G. , Katainen, Riku , Hirvonen, Elina A. M. , Karhu, Auli , Taira, Aurora , Tanskanen, Tomas , Alkodsi, Amjad , Taipale, Minna , Morgunova, Ekaterina , Franssila, Kaarle , Lehtonen, Rainer , Mäkinen, Markus , Aittomäki, Kristiina , Palotie, Aarno , Kurki, Mitja I. , Pietiläinen, Olli , Hilpert, Morgane , Saarentaus, Elmo , Niinimäki, Jaakko , Junttila, Juhani , Kaikkonen, Kari , Vahteristo, Pia , Skoda, Radek C. , Seppänen, Mikko R. J. , Eklund, Kari K. , Taipale, Jussi , Kilpivaara, Outi and Aaltonen, Lauri A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Clonal hematopoiesis driven by somatic heterozygous
TET2
loss is linked to malignant degeneration via consequent aberrant DNA methylation, and possibly to cardiovascular disease via increased cytokine and chemokine expression as reported in mice. Here, we discover a germline
TET2
mutation in a lymphoma family. We observe neither unusual...
Alternative Titles
Full title
Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans
Authors, Artists and Contributors
Author / Creator
Kuismin, Outi
Rajamäki, Kristiina
Ristolainen, Heikki
Aavikko, Mervi
Kondelin, Johanna
Saarinen, Silva
Berta, Davide G.
Katainen, Riku
Hirvonen, Elina A. M.
Karhu, Auli
Taira, Aurora
Tanskanen, Tomas
Alkodsi, Amjad
Taipale, Minna
Morgunova, Ekaterina
Franssila, Kaarle
Lehtonen, Rainer
Mäkinen, Markus
Aittomäki, Kristiina
Palotie, Aarno
Kurki, Mitja I.
Pietiläinen, Olli
Hilpert, Morgane
Saarentaus, Elmo
Niinimäki, Jaakko
Junttila, Juhani
Kaikkonen, Kari
Vahteristo, Pia
Skoda, Radek C.
Seppänen, Mikko R. J.
Eklund, Kari K.
Taipale, Jussi
Kilpivaara, Outi
Aaltonen, Lauri A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_46989eed5d5545f397b38c9c2843f70f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_46989eed5d5545f397b38c9c2843f70f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09198-7
