Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hipp...
Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Quiescence is essential for the long-term maintenance of adult stem cells but how stem cells maintain quiescence is poorly understood. Here, we show that neural stem cells (NSCs) in the adult mouse hippocampus actively transcribe the pro-activation factor Ascl1 regardless of their activated or quiescent states. We found that the inhibitor of DNA bi...
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Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells
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TN_cdi_doaj_primary_oai_doaj_org_article_46c1dcf29c0e4f749dc6f364aa91f9ca
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_46c1dcf29c0e4f749dc6f364aa91f9ca
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.48561
