Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer
Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer
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Author / Creator
Liu, Jingyi , Duan, Zhibing , Guo, Weijie , Zeng, Lei , Wu, Yadi , Chen, Yule , Tai, Fang , Wang, Yifan , Lin, Yiwei , Zhang, Qiang , He, Yanling , Deng, Jiong , Stewart, Rachel L. , Wang, Chi , Lin, Pengnian Charles , Ghaffari, Saghi , Evers, B. Mark , Liu, Suling , Zhou, Ming-Ming , Zhou, Binhua P. and Shi, Jian
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
BRD4 assembles transcriptional machinery at gene super-enhancer regions and governs the expression of genes that are critical for cancer progression. However, it remains unclear whether BRD4-mediated gene transcription is required for tumor cells to develop drug resistance. Our data show that prolonged treatment of luminal breast cancer cells with...
Alternative Titles
Full title
Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_47361ecca973405cbbf1642486398298
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_47361ecca973405cbbf1642486398298
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07258-y
