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TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_477038968eb04a52a24c1167301fe0f5

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

About this item

Full title

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

Publisher

England: eLife Sciences Publications Ltd

Journal title

eLife, 2021-08, Vol.10

Language

English

Formats

Publication information

Publisher

England: eLife Sciences Publications Ltd

More information

Scope and Contents

Contents

The signalling pathways that maintain primed human pluripotent stem cells (hPSCs) have been well characterised, revealing a critical role for TGFβ/Activin/Nodal signalling. In contrast, the signalling requirements of naïve human pluripotency have not been fully established. Here, we demonstrate that TGFβ signalling is required to maintain naïve hPS...

Alternative Titles

Full title

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_477038968eb04a52a24c1167301fe0f5

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_477038968eb04a52a24c1167301fe0f5

Other Identifiers

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.67259

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