Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate...
Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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DNA derived from chemotherapeutics-killed tumor cells is one of the most important damage-associated molecular patterns that can activate the cGAS-STING (cyclic GMP-AMP synthase—stimulator of interferon genes) pathway in antigen-presenting cells (APCs) and promote antitumor immunity. However, conventional chemotherapy displays limited tumor cell ki...
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Full title
Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity
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TN_cdi_doaj_primary_oai_doaj_org_article_47ef2dad2b6e4c9d8e6cb22518e29c64
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_47ef2dad2b6e4c9d8e6cb22518e29c64
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-39607-x
