Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced...
Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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CRISPR-Cas9 genome editing has promising therapeutic potential for genetic diseases and cancers, but safety could be a concern. Here we use whole genomic analysis by 10x linked-read sequencing and optical genome mapping to interrogate the genome integrity after editing and in comparison to four parental cell lines. In addition to the previously rep...
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Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing
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TN_cdi_doaj_primary_oai_doaj_org_article_4834e286501546e1ae6804e717d5ef28
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4834e286501546e1ae6804e717d5ef28
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-40901-x
