Metabolic engineering of Glarea lozoyensis for high-level production of pneumocandin B0
Metabolic engineering of Glarea lozoyensis for high-level production of pneumocandin B0
About this item
Full title
Author / Creator
Zhang, Xinyi , Cheng, Shu , Yang, Jing , Lu, Li , Deng, Zixin , Bian, Guangkai and Liu, Tiangang
Publisher
Shanghai: Elsevier B.V
Journal title
Language
English
Formats
Publication information
Publisher
Shanghai: Elsevier B.V
Subjects
More information
Scope and Contents
Contents
Pneumocandin B0 (PB0) is a lipohexapeptide synthesized by Glarea lozoyensis and serves as the precursor for the widely used antifungal drug caspofungin acetate (Cancidas®). However, the low titer of PB0 results in fermentation and purification costs during caspofungin production, limiting its widespread clinical application. Here, we engineered an...
Alternative Titles
Full title
Metabolic engineering of Glarea lozoyensis for high-level production of pneumocandin B0
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4852c6ff608e4119bbf0482bd29755f3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4852c6ff608e4119bbf0482bd29755f3
Other Identifiers
ISSN
2405-805X
E-ISSN
2405-805X
DOI
10.1016/j.synbio.2024.12.008
