ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia
ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia
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Author / Creator
Micol, Jean-Baptiste , Pastore, Alessandro , Inoue, Daichi , Duployez, Nicolas , Kim, Eunhee , Lee, Stanley Chun-Wei , Durham, Benjamin H. , Chung, Young Rock , Cho, Hana , Zhang, Xiao Jing , Yoshimi, Akihide , Krivtsov, Andrei , Koche, Richard , Solary, Eric , Sinha, Amit , Preudhomme, Claude and Abdel-Wahab, Omar
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Additional sex combs-like (ASXL) proteins are mammalian homologues of additional sex combs (Asx), a regulator of trithorax and polycomb function in
Drosophila.
While there has been great interest in
ASXL1
due to its frequent mutation in leukemia, little is known about its paralog ASXL2, which is frequently mutated in acute myeloid leuke...
Alternative Titles
Full title
ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia
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TN_cdi_doaj_primary_oai_doaj_org_article_4858a0bedd1541a2a819f03ad5087413
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4858a0bedd1541a2a819f03ad5087413
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15429
