[18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of...
[18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data
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Author / Creator
Ballweg, Anna , Klaus, Carolin , Vogler, Letizia , Katzdobler, Sabrina , Wind, Karin , Zatcepin, Artem , Ziegler, Sibylle I. , Secgin, Birkan , Eckenweber, Florian , Bohr, Bernd , Bernhardt, Alexander , Fietzek, Urban , Rauchmann, Boris-Stephan , Stoecklein, Sophia , Quach, Stefanie , Beyer, Leonie , Scheifele, Maximilian , Simmet, Marcel , Joseph, Emanuel , Lindner, Simon , Berg, Isabella , Koglin, Norman , Mueller, Andre , Stephens, Andrew W. , Bartenstein, Peter , Tonn, Joerg C. , Albert, Nathalie L. , Kümpfel, Tania , Kerschensteiner, Martin , Perneczky, Robert , Levin, Johannes , Paeger, Lars , Herms, Jochen and Brendel, Matthias
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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More information
Scope and Contents
Contents
Reactive gliosis is a common pathological hallmark of CNS pathology resulting from neurodegeneration and neuroinflammation. In this study we investigate the capability of a novel monoamine oxidase B (MAO-B) PET ligand to monitor reactive astrogliosis in a transgenic mouse model of Alzheimer`s disease (AD). Furthermore, we performed a pilot study in...
Alternative Titles
Full title
[18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data
Authors, Artists and Contributors
Author / Creator
Klaus, Carolin
Vogler, Letizia
Katzdobler, Sabrina
Wind, Karin
Zatcepin, Artem
Ziegler, Sibylle I.
Secgin, Birkan
Eckenweber, Florian
Bohr, Bernd
Bernhardt, Alexander
Fietzek, Urban
Rauchmann, Boris-Stephan
Stoecklein, Sophia
Quach, Stefanie
Beyer, Leonie
Scheifele, Maximilian
Simmet, Marcel
Joseph, Emanuel
Lindner, Simon
Berg, Isabella
Koglin, Norman
Mueller, Andre
Stephens, Andrew W.
Bartenstein, Peter
Tonn, Joerg C.
Albert, Nathalie L.
Kümpfel, Tania
Kerschensteiner, Martin
Perneczky, Robert
Levin, Johannes
Paeger, Lars
Herms, Jochen
Brendel, Matthias
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_497126e6fe484a14b58f292c7979ad26
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_497126e6fe484a14b58f292c7979ad26
Other Identifiers
ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-023-02749-2
