Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain
Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme in cholesterol synthesis and target of cholesterol-lowering statin drugs. Accumulation of sterols in endoplasmic reticulum (ER) membranes accelerates degradation of HMGCR, slowing the synthesis of cholesterol. Degradation of HMGCR is inhibited by its binding to UBIA...
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Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain
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TN_cdi_doaj_primary_oai_doaj_org_article_4a056b4f7f0d479aaf606c0207088a37
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a056b4f7f0d479aaf606c0207088a37
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32025-5
