TNIK inhibition abrogates colorectal cancer stemness
TNIK inhibition abrogates colorectal cancer stemness
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Canonical Wnt/β-catenin signalling is essential for maintaining intestinal stem cells, and its constitutive activation has been implicated in colorectal carcinogenesis. We and others have previously identified Traf2- and Nck-interacting kinase (TNIK) as an essential regulatory component of the T-cell factor-4 and β-catenin transcriptional complex....
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Full title
TNIK inhibition abrogates colorectal cancer stemness
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TN_cdi_doaj_primary_oai_doaj_org_article_4a216298e0fc4be591ff7743d3af46e1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a216298e0fc4be591ff7743d3af46e1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12586
