Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity
Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Cell-cycle entry relies on an orderly progression of signaling events. To start, cells first activate the kinase cyclin D-CDK4/6, which leads to eventual inactivation of the retinoblastoma protein Rb. Hours later, cells inactivate APC/C
CDH1
and cross the final commitment point. However, many cells with genetically deleted cyclin Ds, which ac...
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Full title
Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity
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TN_cdi_doaj_primary_oai_doaj_org_article_4a2a815723b8428281f4154d5dbff8d9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a2a815723b8428281f4154d5dbff8d9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18966-9
