Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differen...
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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People with type 2 diabetes mellitus (T2DM) have a 25-fold higher risk of limb loss than non-diabetics due in large part to impaired wound healing. Here, we show that the impaired wound healing phenotype found in T2D mice is recapitulated in lethally irradiated wild type recipients, whose hematopoiesis is reconstituted with hematopoietic stem cells...
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Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages
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TN_cdi_doaj_primary_oai_doaj_org_article_4a2e03c93405462e969dba52018c2d64
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a2e03c93405462e969dba52018c2d64
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02425-z
