Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a...
Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient
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Author / Creator
Osumi, Hiroki , Muroi, Atsushi , Sakahara, Mizuho , Kawachi, Hiroshi , Okamoto, Takuya , Natsume, Yasuko , Yamanaka, Hitomi , Takano, Hiroshi , Kusama, Daisuke , Shinozaki, Eiji , Ooki, Akira , Yamaguchi, Kensei , Ueno, Masashi , Takeuchi, Kengo , Noda, Tetsuo , Nagayama, Satoshi , Koshikawa, Naohiko and Yao, Ryoji
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
RAS signaling is a promising target for colorectal cancer (CRC) therapy, and a variety of selective inhibitors have been developed. However, their use has often failed to demonstrate a significant benefit in CRC patients. Here, we used patient-derived organoids (PDOs) derived from a familial adenomatous polyposis (FAP) patient to analyze the respon...
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Full title
Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4a5d7832b5aa4ee2ae61173e8d40b629
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a5d7832b5aa4ee2ae61173e8d40b629
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-74530-x
