Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
About this item
Full title
Author / Creator
Tang, Qi , Fakih, Hassan H. , Zain UI Abideen, Mohammad , Hildebrand, Samuel R. , Afshari, Khashayar , Gross, Katherine Y. , Sousa, Jacquelyn , Maebius, Allison S. , Bartholdy, Christina , Søgaard, Pia Pernille , Jackerott, Malene , Hariharan, Vignesh , Summers, Ashley , Fan, Xueli , Okamura, Ken , Monopoli, Kathryn R. , Cooper, David A. , Echeverria, Dimas , Bramato, Brianna , McHugh, Nicholas , Furgal, Raymond C. , Dresser, Karen , Winter, Sarah J. , Biscans, Annabelle , Chuprin, Jane , Haddadi, Nazgol-Sadat , Sherman, Shany , Yıldız-Altay, Ümmügülsüm , Rashighi, Mehdi , Richmond, Jillian M. , Bouix-Peter, Claire , Blanchard, Carine , Clauss, Adam , Alterman, Julia F. , Khvorova, Anastasia and Harris, John E.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors show distinct efficacy and safety profiles, likely reflecting variable selectivity for JAK subtypes. Absolute JAK subtype selectivity has not yet been achieved. Here, we rationall...
Alternative Titles
Full title
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
Authors, Artists and Contributors
Author / Creator
Fakih, Hassan H.
Zain UI Abideen, Mohammad
Hildebrand, Samuel R.
Afshari, Khashayar
Gross, Katherine Y.
Sousa, Jacquelyn
Maebius, Allison S.
Bartholdy, Christina
Søgaard, Pia Pernille
Jackerott, Malene
Hariharan, Vignesh
Summers, Ashley
Fan, Xueli
Okamura, Ken
Monopoli, Kathryn R.
Cooper, David A.
Echeverria, Dimas
Bramato, Brianna
McHugh, Nicholas
Furgal, Raymond C.
Dresser, Karen
Winter, Sarah J.
Biscans, Annabelle
Chuprin, Jane
Haddadi, Nazgol-Sadat
Sherman, Shany
Yıldız-Altay, Ümmügülsüm
Rashighi, Mehdi
Richmond, Jillian M.
Bouix-Peter, Claire
Blanchard, Carine
Clauss, Adam
Alterman, Julia F.
Khvorova, Anastasia
Harris, John E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4a8cb6635b9d4fb98e9074b6bcb3b50f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4a8cb6635b9d4fb98e9074b6bcb3b50f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42714-4
