Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
About this item
Full title
Author / Creator
Zuo, Hao , Yang, Dengbao , Yang, Qiwen , Tang, Haidong , Fu, Yang-Xin and Wan, Yihong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
PARP1 and PARP2 dual inhibitors, such as olaparib, have been recently FDA approved for the treatment of advanced breast and ovarian cancers. However, their effects on bone mass and bone metastasis are unknown. Here we show that olaparib increases breast cancer bone metastasis through PARP2, but not PARP1, specifically in the myeloid lineage, but no...
Alternative Titles
Full title
Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4ab0627a85d644db82a8b2b8a0f4f8d7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4ab0627a85d644db82a8b2b8a0f4f8d7
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15429-z
