A cell‐based model system links chromothripsis with hyperploidy
A cell‐based model system links chromothripsis with hyperploidy
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Author / Creator
Mardin, Balca R , Drainas, Alexandros P , Waszak, Sebastian M , Weischenfeldt, Joachim , Isokane, Mayumi , Stütz, Adrian M , Raeder, Benjamin , Efthymiopoulos, Theocharis , Buccitelli, Christopher , Segura‐Wang, Maia , Northcott, Paul , Pfister, Stefan M , Lichter, Peter , Ellenberg, Jan and Korbel, Jan O
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
A remarkable observation emerging from recent cancer genome analyses is the identification of chromothripsis as a one‐off genomic catastrophe, resulting in massive somatic DNA structural rearrangements (SRs). Largely due to lack of suitable model systems, the mechanistic basis of chromothripsis has remained elusive. We developed an integrative meth...
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Full title
A cell‐based model system links chromothripsis with hyperploidy
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4ae82bd2680e4838bba1e601082ba12c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4ae82bd2680e4838bba1e601082ba12c
Other Identifiers
ISSN
1744-4292
E-ISSN
1744-4292
DOI
10.15252/msb.20156505
