A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain
A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Stress can induce cell surface expression of MHC-like ligands, including MICA, that activate NK cells. Human cytomegalovirus (HCMV) glycoprotein US9 downregulates the activating immune ligand MICA*008 to avoid NK cell activation, but the underlying mechanism remains unclear. Here, we show that the N-terminal signal peptide is the major US9 function...
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A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain
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TN_cdi_doaj_primary_oai_doaj_org_article_4b12a5f9952c4c4db91422b8ba6f827e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4b12a5f9952c4c4db91422b8ba6f827e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21983-x
