Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
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Author / Creator
Kikuchi, Koichi , Saigusa, Daisuke , Kanemitsu, Yoshitomi , Matsumoto, Yotaro , Thanai, Paxton , Suzuki, Naoto , Mise, Koki , Yamaguchi, Hiroaki , Nakamura, Tomohiro , Asaji, Kei , Mukawa, Chikahisa , Tsukamoto, Hiroki , Sato, Toshihiro , Oikawa, Yoshitsugu , Iwasaki, Tomoyuki , Oe, Yuji , Tsukimi, Tomoya , Fukuda, Noriko N. , HO, Hsin-Jung , Nanto-Hara, Fumika , Ogura, Jiro , Saito, Ritsumi , Nagao, Shizuko , Ohsaki, Yusuke , Shimada, Satoshi , Suzuki, Takehiro , Toyohara, Takafumi , Mishima, Eikan , Shima, Hisato , Akiyama, Yasutoshi , Akiyama, Yukako , Ichijo, Mariko , Matsuhashi, Tetsuro , Matsuo, Akihiro , Ogata, Yoshiaki , Yang, Ching-Chin , Suzuki, Chitose , Breeggemann, Matthew C. , Heymann, Jurgen , Shimizu, Miho , Ogawa, Susumu , Takahashi, Nobuyuki , Suzuki, Takashi , Owada, Yuji , Kure, Shigeo , Mano, Nariyasu , Soga, Tomoyoshi , Wada, Takashi , Kopp, Jeffrey B. , Fukuda, Shinji , Hozawa, Atsushi , Yamamoto, Masayuki , Ito, Sadayoshi , Wada, Jun , Tomioka, Yoshihisa and Abe, Takaaki
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the progression of diabetes in rats overexpressing human uremic toxin transporter SLCO4C1 in the kidne...
Alternative Titles
Full title
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
Authors, Artists and Contributors
Author / Creator
Saigusa, Daisuke
Kanemitsu, Yoshitomi
Matsumoto, Yotaro
Thanai, Paxton
Suzuki, Naoto
Mise, Koki
Yamaguchi, Hiroaki
Nakamura, Tomohiro
Asaji, Kei
Mukawa, Chikahisa
Tsukamoto, Hiroki
Sato, Toshihiro
Oikawa, Yoshitsugu
Iwasaki, Tomoyuki
Oe, Yuji
Tsukimi, Tomoya
Fukuda, Noriko N.
HO, Hsin-Jung
Nanto-Hara, Fumika
Ogura, Jiro
Saito, Ritsumi
Nagao, Shizuko
Ohsaki, Yusuke
Shimada, Satoshi
Suzuki, Takehiro
Toyohara, Takafumi
Mishima, Eikan
Shima, Hisato
Akiyama, Yasutoshi
Akiyama, Yukako
Ichijo, Mariko
Matsuhashi, Tetsuro
Matsuo, Akihiro
Ogata, Yoshiaki
Yang, Ching-Chin
Suzuki, Chitose
Breeggemann, Matthew C.
Heymann, Jurgen
Shimizu, Miho
Ogawa, Susumu
Takahashi, Nobuyuki
Suzuki, Takashi
Owada, Yuji
Kure, Shigeo
Mano, Nariyasu
Soga, Tomoyoshi
Wada, Takashi
Kopp, Jeffrey B.
Fukuda, Shinji
Hozawa, Atsushi
Yamamoto, Masayuki
Ito, Sadayoshi
Wada, Jun
Tomioka, Yoshihisa
Abe, Takaaki
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4b7ee8aaa8cd44e3ba881e3d9e920e28
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4b7ee8aaa8cd44e3ba881e3d9e920e28
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09735-4
