β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet fu...
β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network
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Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Diabetes is caused by the inability of electrically coupled, functionally heterogeneous β-cells within the pancreatic islet to provide adequate insulin secretion. Functional networks have been used to represent synchronized oscillatory [Ca
] dynamics and to study β-cell subpopulations, which play an important role in driving islet function. The...
Alternative Titles
Full title
β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network
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TN_cdi_doaj_primary_oai_doaj_org_article_4b9836aacff5411489a467e2968afa6b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4b9836aacff5411489a467e2968afa6b
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.83147
