Safety and pharmacokinetics of VRC07-523LS administered via different routes and doses (HVTN 127/HPT...
Safety and pharmacokinetics of VRC07-523LS administered via different routes and doses (HVTN 127/HPTN 087): A Phase I randomized clinical trial
About this item
Full title
Author / Creator
Walsh, Stephen R. , Gay, Cynthia L. , Karuna, Shelly T. , Hyrien, Ollivier , Skalland, Timothy , Mayer, Kenneth H. , Sobieszczyk, Magdalena E. , Baden, Lindsey R. , Goepfert, Paul A. , del Rio, Carlos , Pantaleo, Guiseppe , Andrew, Philip , Karg, Carissa , He, Zonglin , Lu, Huiyin , Paez, Carmen A. , Baumblatt, Jane A. G. , Polakowski, Laura L. , Chege, Wairimu , Anderson, Maija A. , Janto, Sophie , Han, Xue , Huang, Yunda , Dumond, Julie , Ackerman, Margaret E. , McDermott, Adrian B. , Flach, Britta , Piwowar-Manning, Estelle , Seaton, Kelly , Tomaras, Georgia D. , Montefiori, David C. , Gama, Lucio , Mascola, John R. , for the HVTN 127/HPTN 087 Study Team and HVTN 127/HPTN 087 Study Team
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Broadly neutralizing antibodies (bnAbs) are a promising approach for HIV-1 prevention. In the Antibody Mediated Prevention (AMP) trials, a CD4-binding site targeting bnAb, VRC01, administered intravenously (IV), demonstrated 75% prevention efficacy against highly neutralization-sensitive viruses but was ineffective against less sensitive viruses. V...
Alternative Titles
Full title
Safety and pharmacokinetics of VRC07-523LS administered via different routes and doses (HVTN 127/HPTN 087): A Phase I randomized clinical trial
Authors, Artists and Contributors
Author / Creator
Gay, Cynthia L.
Karuna, Shelly T.
Hyrien, Ollivier
Skalland, Timothy
Mayer, Kenneth H.
Sobieszczyk, Magdalena E.
Baden, Lindsey R.
Goepfert, Paul A.
del Rio, Carlos
Pantaleo, Guiseppe
Andrew, Philip
Karg, Carissa
He, Zonglin
Lu, Huiyin
Paez, Carmen A.
Baumblatt, Jane A. G.
Polakowski, Laura L.
Chege, Wairimu
Anderson, Maija A.
Janto, Sophie
Han, Xue
Huang, Yunda
Dumond, Julie
Ackerman, Margaret E.
McDermott, Adrian B.
Flach, Britta
Piwowar-Manning, Estelle
Seaton, Kelly
Tomaras, Georgia D.
Montefiori, David C.
Gama, Lucio
Mascola, John R.
for the HVTN 127/HPTN 087 Study Team
HVTN 127/HPTN 087 Study Team
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4be70ce338214ab0a34f240e9ededde1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4be70ce338214ab0a34f240e9ededde1
Other Identifiers
ISSN
1549-1676,1549-1277
E-ISSN
1549-1676
DOI
10.1371/journal.pmed.1004329
