133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and...
133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
About this item
Full title
Author / Creator
Campbell, Hamish , Fleming, Nicholas , Roth, Imogen , Mehta, Sunali , Wiles, Anna , Williams, Gail , Vennin, Claire , Arsic, Nikola , Parkin, Ashleigh , Pajic, Marina , Munro, Fran , McNoe, Les , Black, Michael , McCall, John , Slatter, Tania L. , Timpson, Paul , Reddel, Roger , Roux, Pierre , Print, Cristin , Baird, Margaret A. and Braithwaite, Antony W.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
∆122p53
mice (a model of ∆133p53 isoform) are tumour-prone, have extensive inflammation and elevated serum IL-6. To investigate the role of IL-6 we crossed
∆122p53
mice with
IL-6
null mice. Here we show that loss of
IL-6
reduced JAK-STAT signalling, tumour incidence and metastasis. We also show that ∆122p53 activates RhoA-ROCK...
Alternative Titles
Full title
133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
Authors, Artists and Contributors
Author / Creator
Fleming, Nicholas
Roth, Imogen
Mehta, Sunali
Wiles, Anna
Williams, Gail
Vennin, Claire
Arsic, Nikola
Parkin, Ashleigh
Pajic, Marina
Munro, Fran
McNoe, Les
Black, Michael
McCall, John
Slatter, Tania L.
Timpson, Paul
Reddel, Roger
Roux, Pierre
Print, Cristin
Baird, Margaret A.
Braithwaite, Antony W.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4c1f6ec1d79b419c8e9e3bfbf63ac5e5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4c1f6ec1d79b419c8e9e3bfbf63ac5e5
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02408-0
