SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic...
SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction
About this item
Full title
Author / Creator
Flaherty, 3rd, Stephen E , Bezy, Olivier , Paulhus, Brianna LaCarubba , Song, LouJin , Piper, Mary , Pang, Jincheng , Park, Yoson , Asano, Shoh , Lien, Yu-Chin , Griffin, John D , Robertson, Andrew , Opsahl, Alan , Shanthappa, Dinesh Hirenallur , Ahn, Youngwook , Pashos, Evanthia , Simmons, Rebecca A , Birnbaum, Morris J and Wu, Zhidan
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publication information
Publisher
England: eLife Science Publications, Ltd
Subjects
More information
Scope and Contents
Contents
From a forward mutagenetic screen to discover mutations associated with obesity, we identified mutations in the
gene linked to metabolic dysfunction in mice. Here, we show that SPAG7 KO mice are born smaller and develop obesity and glucose intolerance in adulthood. This obesity does not stem from hyperphagia, but a decrease in energy expenditure...
Alternative Titles
Full title
SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction
Authors, Artists and Contributors
Author / Creator
Bezy, Olivier
Paulhus, Brianna LaCarubba
Song, LouJin
Piper, Mary
Pang, Jincheng
Park, Yoson
Asano, Shoh
Lien, Yu-Chin
Griffin, John D
Robertson, Andrew
Opsahl, Alan
Shanthappa, Dinesh Hirenallur
Ahn, Youngwook
Pashos, Evanthia
Simmons, Rebecca A
Birnbaum, Morris J
Wu, Zhidan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4c48137f953943ab9ab7d2ee4fda5031
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4c48137f953943ab9ab7d2ee4fda5031
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.91114
