Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation
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Author / Creator
Zhou, Enchen , Ge, Xiaoke , Nakashima, Hiroyuki , Li, Rumei , van der Zande, Hendrik J P , Liu, Cong , Li, Zhuang , Müller, Christoph , Bracher, Franz , Mohammed, Yassene , de Boer, Jan Freark , Kuipers, Folkert , Guigas, Bruno , Glass, Christopher K , Rensen, Patrick C N , Giera, Martin and Wang, Yanan
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Liver X receptor (LXR) agonism has theoretical potential for treating NAFLD/NASH, but synthetic agonists induce hyperlipidemia in preclinical models. Desmosterol, which is converted by Δ24‐dehydrocholesterol reductase (DHCR24) into cholesterol, is a potent endogenous LXR agonist with anti‐inflammatory properties. We aimed to investigate the effects...
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Full title
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation
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TN_cdi_doaj_primary_oai_doaj_org_article_4c911682d99b44c88efeac537e3e77c7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4c911682d99b44c88efeac537e3e77c7
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ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.202216845
