Novel, clinically relevant genomic patterns identified by comprehensive genomic profiling in ATRX-de...
Novel, clinically relevant genomic patterns identified by comprehensive genomic profiling in ATRX-deficient IDH-wildtype adult high-grade gliomas
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Glioblastomas are the most common IDH-wildtype adult high-grade gliomas, frequently harboring mutations in the
TERT
gene promoter (
pTERT
) and utilizing the subsequent telomerase overexpression for telomere length maintenance. However, some rare cases show loss of ATRX and use alternative mechanisms of telomere lengthening. In this stu...
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Full title
Novel, clinically relevant genomic patterns identified by comprehensive genomic profiling in ATRX-deficient IDH-wildtype adult high-grade gliomas
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TN_cdi_doaj_primary_oai_doaj_org_article_4cd57e2d38044665a2b3776f7f0146ef
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4cd57e2d38044665a2b3776f7f0146ef
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-45786-w
