Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique pharmacokinetic characteristics. OPC-163493 shows a...
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Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
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TN_cdi_doaj_primary_oai_doaj_org_article_4cf4897abcfc4f0d9a71c0c81db9eeb9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4cf4897abcfc4f0d9a71c0c81db9eeb9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09911-6
