Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesog...
Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings
About this item
Full title
Author / Creator
Chim, Shek Man , Howell, Kristen , Dronzek, John , Wu, Weizhen , Van Hout, Cristopher , Ferreira, Manuel AR , Ye, Bin , Li, Alexander , Brydges, Susannah , Arunachalam, Vinayagam , Marcketta, Anthony , Locke, Adam E , Bovijn, Jonas , Verweij, Niek , De, Tanima , Lotta, Luca , Mitnaul, Lyndon , LeBlanc, Michelle , Center, Regeneron Genetics , Carey, David J , Melander, Olle , Shuldiner, Alan , Karalis, Katia , Economides, Aris N , Nistala, Harikiran , DiscovEHR collaboration and Regeneron Genetics Center
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publication information
Publisher
England: eLife Science Publications, Ltd
Subjects
More information
Scope and Contents
Contents
Recent studies have revealed a role for zinc in insulin secretion and glucose homeostasis. Randomized placebo-controlled zinc supplementation trials have demonstrated improved glycemic traits in patients with type II diabetes (T2D). Moreover, rare loss-of-function variants in the zinc efflux transporter
SLC30A8
reduce T2D risk. Despite this a...
Alternative Titles
Full title
Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings
Authors, Artists and Contributors
Author / Creator
Howell, Kristen
Dronzek, John
Wu, Weizhen
Van Hout, Cristopher
Ferreira, Manuel AR
Ye, Bin
Li, Alexander
Brydges, Susannah
Arunachalam, Vinayagam
Marcketta, Anthony
Locke, Adam E
Bovijn, Jonas
Verweij, Niek
De, Tanima
Lotta, Luca
Mitnaul, Lyndon
LeBlanc, Michelle
Center, Regeneron Genetics
Carey, David J
Melander, Olle
Shuldiner, Alan
Karalis, Katia
Economides, Aris N
Nistala, Harikiran
DiscovEHR collaboration
Regeneron Genetics Center
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4cfb8adbbf2e476a8a97ea22b5553ed1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4cfb8adbbf2e476a8a97ea22b5553ed1
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.90419
