Quantitative systems pharmacology model‐based investigation of adverse gastrointestinal events assoc...
Quantitative systems pharmacology model‐based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3‐kinase inhibitors
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United States: John Wiley & Sons, Inc
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Language
English
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Publisher
United States: John Wiley & Sons, Inc
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Several PI3K inhibitors are in clinical development for the treatment of various forms of cancers, including pan‐PI3K inhibitors targeting all four PI3K isoforms (α, β, γ, and δ), and isoform‐selective inhibitors. Diarrhea and immune‐mediated colitis are among the adverse events observed with PI3K inhibition which limits the maximal tolerated dose....
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Quantitative systems pharmacology model‐based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3‐kinase inhibitors
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TN_cdi_doaj_primary_oai_doaj_org_article_4d3f8999655d4cd4aa9f1a6f87ba8b9e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4d3f8999655d4cd4aa9f1a6f87ba8b9e
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ISSN
2163-8306
E-ISSN
2163-8306
DOI
10.1002/psp4.12749
