Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and auto...
Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The autophagic degradation of misfolded and ubiquitinated proteins is important for cellular homeostasis. In this process, which is governed by cargo receptors, ubiquitinated proteins are condensed into larger structures and subsequently become targets for the autophagy machinery. Here we employ in vitro reconstitution and cell biology to define th...
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Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation
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TN_cdi_doaj_primary_oai_doaj_org_article_4db780a5a06e48a0bc6214ed5a5ead08
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4db780a5a06e48a0bc6214ed5a5ead08
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25572-w
