Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reve...
Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Senescence is a tumor suppression mechanism defined by stable proliferation arrest. Here we demonstrate that the known synthetic lethal interaction between poly(ADP-ribose) polymerase 1 inhibitors (PARPi) and DNA repair triggers p53-independent ovarian cancer cell senescence defined by senescence-associated phenotypic hallmarks including DNA-SCARS,...
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Full title
Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
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TN_cdi_doaj_primary_oai_doaj_org_article_4e2c1618e64c4bbe831260ba6926f628
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4e2c1618e64c4bbe831260ba6926f628
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10460-1
