PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neuro...
PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Mutations in PTEN-induced kinase 1 (PINK1) result in a recessive familial form of Parkinson’s disease (PD). PINK1 loss is associated with mitochondrial Ca
2+
mishandling, mitochondrial dysfunction, as well as increased neuronal vulnerability. Here we demonstrate that PINK1 directly interacts with and phosphorylates LETM1 at Thr192 in vitro. P...
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PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
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TN_cdi_doaj_primary_oai_doaj_org_article_4ea42cdc1afd4b7ba93863559be370d3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4ea42cdc1afd4b7ba93863559be370d3
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01435-1
