Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity
Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Mechanosensitive PIEZO2 ion channels play roles in touch, proprioception, and inflammatory pain. Currently, there are no small molecule inhibitors that selectively inhibit PIEZO2 over PIEZO1. The TMEM120A protein was shown to inhibit PIEZO2 while leaving PIEZO1 unaffected. Here we find that TMEM120A expression elevates cellular levels of phosphatid...
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Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity
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TN_cdi_doaj_primary_oai_doaj_org_article_4ee9d394b91046eea2d8b6cd0bf1f855
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4ee9d394b91046eea2d8b6cd0bf1f855
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-51181-4
