Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension
About this item
Full title
Author / Creator
Sindi, Hebah A. , Russomanno, Giusy , Satta, Sandro , Abdul-Salam, Vahitha B. , Jo, Kyeong Beom , Qazi-Chaudhry, Basma , Ainscough, Alexander J. , Szulcek, Robert , Jan Bogaard, Harm , Morgan, Claire C. , Pullamsetti, Soni S. , Alzaydi, Mai M. , Rhodes, Christopher J. , Piva, Roberto , Eichstaedt, Christina A. , Grünig, Ekkehard , Wilkins, Martin R. and Wojciak-Stothard, Beata
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like factor 2 (KLF2) are compromised in PAH. Here, we show that KLF2-induced exosomal microRNAs, miR-181a-5p and miR-324-5p act together to attenuate pulmonary vascular r...
Alternative Titles
Full title
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension
Authors, Artists and Contributors
Author / Creator
Russomanno, Giusy
Satta, Sandro
Abdul-Salam, Vahitha B.
Jo, Kyeong Beom
Qazi-Chaudhry, Basma
Ainscough, Alexander J.
Szulcek, Robert
Jan Bogaard, Harm
Morgan, Claire C.
Pullamsetti, Soni S.
Alzaydi, Mai M.
Rhodes, Christopher J.
Piva, Roberto
Eichstaedt, Christina A.
Grünig, Ekkehard
Wilkins, Martin R.
Wojciak-Stothard, Beata
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4eebb969beec4b25a1d7906be6c74e47
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4eebb969beec4b25a1d7906be6c74e47
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-14966-x
