NOTCH1 is a mechanosensor in adult arteries
NOTCH1 is a mechanosensor in adult arteries
About this item
Full title
Author / Creator
Mack, Julia J. , Mosqueiro, Thiago S. , Archer, Brian J. , Jones, William M. , Sunshine, Hannah , Faas, Guido C. , Briot, Anais , Aragón, Raquel L. , Su, Trent , Romay, Milagros C. , McDonald, Austin I. , Kuo, Cheng-Hsiang , Lizama, Carlos O. , Lane, Timothy F. , Zovein, Ann C. , Fang, Yun , Tarling, Elizabeth J. , de Aguiar Vallim, Thomas Q. , Navab, Mohamad , Fogelman, Alan M. , Bouchard, Louis S. and Iruela-Arispe, M. Luisa
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Endothelial cells transduce mechanical forces from blood flow into intracellular signals required for vascular homeostasis. Here we show that endothelial NOTCH1 is responsive to shear stress, and is necessary for the maintenance of junctional integrity, cell elongation, and suppression of proliferation, phenotypes induced by laminar shear stress. N...
Alternative Titles
Full title
NOTCH1 is a mechanosensor in adult arteries
Authors, Artists and Contributors
Author / Creator
Mosqueiro, Thiago S.
Archer, Brian J.
Jones, William M.
Sunshine, Hannah
Faas, Guido C.
Briot, Anais
Aragón, Raquel L.
Su, Trent
Romay, Milagros C.
McDonald, Austin I.
Kuo, Cheng-Hsiang
Lizama, Carlos O.
Lane, Timothy F.
Zovein, Ann C.
Fang, Yun
Tarling, Elizabeth J.
de Aguiar Vallim, Thomas Q.
Navab, Mohamad
Fogelman, Alan M.
Bouchard, Louis S.
Iruela-Arispe, M. Luisa
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4f0c26b8468d4646bb1e62081f693165
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4f0c26b8468d4646bb1e62081f693165
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01741-8
