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Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4f20b420b7274e21b3fd2be2a1aa131b

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

About this item

Full title

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2018-09, Vol.9 (1), p.3693-14, Article 3693

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

As the sole target of broadly neutralizing antibodies (bnAbs) to HIV, the envelope glycoprotein (Env) trimer is the focus of vaccination strategies designed to elicit protective bnAbs in humans. Because HIV Env is densely glycosylated with 75–90 N-glycans per trimer, most bnAbs use or accommodate them in their binding epitope, making the glycosylat...

Alternative Titles

Full title

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_4f20b420b7274e21b3fd2be2a1aa131b

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4f20b420b7274e21b3fd2be2a1aa131b

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-018-06121-4

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