PARP4 deficiency enhances sensitivity to ATM inhibitor by impairing DNA damage repair in melanoma
PARP4 deficiency enhances sensitivity to ATM inhibitor by impairing DNA damage repair in melanoma
About this item
Full title
Author / Creator
Li, Yuehua , Liu, Yu , Ma, Jingjing , Yang, Yuqi , Yue, Qiao , Zhu, Guannan , Guo, Weinan , Gao, Tianwen , Shi, Qiong and Li, Chunying
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Besides the important pathogenic mechanisms of melanoma, including BRAF-driven and immunosuppressive microenvironment, genomic instability and abnormal DNA double-strand breaks (DSB) repair are significant driving forces for its occurrence and development. This suggests investigating novel therapeutic strategies from the synthetic lethality perspec...
Alternative Titles
Full title
PARP4 deficiency enhances sensitivity to ATM inhibitor by impairing DNA damage repair in melanoma
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4fbe62a3454b40198521f7280b934e63
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4fbe62a3454b40198521f7280b934e63
Other Identifiers
ISSN
2058-7716
E-ISSN
2058-7716
DOI
10.1038/s41420-025-02296-0
