Engineering designer beta cells with a CRISPR-Cas9 conjugation platform
Engineering designer beta cells with a CRISPR-Cas9 conjugation platform
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Genetically fusing protein domains to Cas9 has yielded several transformative technologies; however, the genetic modifications are limited to natural polypeptide chains at the Cas9 termini, which excludes a diverse array of molecules useful for gene editing. Here, we report chemical modifications that allow site-specific and multiple-site conjugati...
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Full title
Engineering designer beta cells with a CRISPR-Cas9 conjugation platform
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TN_cdi_doaj_primary_oai_doaj_org_article_4fe0e563f9774b8ea8aa70b031449f72
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4fe0e563f9774b8ea8aa70b031449f72
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17725-0
