Genetic and Functional Differences between Duplicated Zebrafish Genes for Human SCN1A
Genetic and Functional Differences between Duplicated Zebrafish Genes for Human SCN1A
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Switzerland: MDPI AG
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English
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Switzerland: MDPI AG
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There are currently seven different zebrafish strains that model Dravet Syndrome, a severe childhood form of epilepsy. These models are based on a set of duplicated genes, scn1laa and scn1lab, which are the homologs for human SCN1A. Disrupting one of the genes would mimic a heterozygous disease state in humans, as the paralog gene is still present....
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Genetic and Functional Differences between Duplicated Zebrafish Genes for Human SCN1A
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TN_cdi_doaj_primary_oai_doaj_org_article_4fe5bd423bb54af689826500e3aca28c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4fe5bd423bb54af689826500e3aca28c
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ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells11030454
