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CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degrad...

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degrad...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_501fe4c8a5e9423ca573e0d9f455d0b2

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

About this item

Full title

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

Publisher

London: Nature Publishing Group UK

Journal title

Signal transduction and targeted therapy, 2024-07, Vol.9 (1), p.189-14, Article 189

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Neuroendocrine (NE) transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor prognosis. Up to date, even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53 (
TP53)
and Retinoblastoma Transcriptional Corepressor 1
(RB1)
mutations...

Alternative Titles

Full title

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_501fe4c8a5e9423ca573e0d9f455d0b2

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_501fe4c8a5e9423ca573e0d9f455d0b2

Other Identifiers

ISSN

2059-3635,2095-9907

E-ISSN

2059-3635

DOI

10.1038/s41392-024-01908-y

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