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Alpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for Parkinson's disease (PD). Interestingly, a common molecular alteration am...

Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes

10.1038/s41531-022-00314-x