Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and mic...
Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Driver mutations and chromosomal aneuploidy are major determinants of tumorigenesis that exhibit complex relationships. Here, we identify associations between driver mutations and chromosomal aberrations that define two tumor clusters, with distinct regimes of tumor evolution underpinned by unique sets of mutations in different components of DNA da...
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Full title
Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
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TN_cdi_doaj_primary_oai_doaj_org_article_508a4ed569754b8f9b56fc8d430a3718
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_508a4ed569754b8f9b56fc8d430a3718
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15094-2
